Fundamentals of Vaccine Manufacture


Vaccines play a vital role in human health and the defence against infectious diseases. Awareness of the importance of vaccines has never been as high as during the COVID-19 pandemic.  This course aims to give a general overview of the various vaccine modalities; from live or attenuated viruses to recombinant protein and DNA/mRNA-based vaccines. This course will also describe the various methods of manufacture of these different vaccines from upstream to downstream to fill-finish and quality control. Furthermore, practical sessions will allow the trainee to work with the equipment used in these manufacturing processes and gain hands-on experience of the associated techniques.

Key topics covered

  • An Overview of Vaccines by type and manufacturing strategy will be outlined.
  • Cryopreservation in the context of vaccine manufacturing will be discussed.
  • Aseptic Handling will be explained.
  • Aseptic handling will be practiced (onsite only).
  • An Overview of Upstream manufacturing for vaccines will be provided.
  • Cell culture operations for vaccine manufacturing will be practiced (onsite only).
  • Hands on set-Up, Installation and Operation of various bioreactor formats used in Vaccine manufacturing (onsite only).
  • Harvest operations for vaccine manufacturing will be discussed including different strategies and equipment.
  • Hands on set-up and operation of harvest equipment (onsite only).
  • Aseptic filling of vaccines will be outlined including key operations and equipment including filling and barrier systems.
  • Hands on practice with filling equipment including Aseptic operations in a filling line and barrier system.

Who should attend

This course is designed for operators, technical staff, engineers, and managers wishing to increase their knowledge of the strategies used in vaccine manufacturing.

What do Attendees Obtain on Completion?

A competency based assessment will be undertaken at the end of the course and a cert offered on completion.


Fundamentals of Vaccine Manufacture


4 - Fundamentals of vaccine manufacture

Course Format

Blended; Online & Onsite Training

  • Two mornings of online theory
  • Two days NIBRT practicals

Dates & Price

  • Course 1
    18/11/2024 - 19/11/2024

    NIBRT Online Course (does not cover practicals)


    4 Places Remaining

  • Course 2
    18/11/2024 - 26/11/2024

    Full Course:
    18 – 19 November (Online)
    25 -26 November (Practicals)


    6 Places Remaining

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