The Lyophilisation Centre at NIBRT


The Lyophilisation Centre at NIBRT

The Lyophilisation Centre at NIBRT is a leading centre of innovation in training and research in the lyophilisation of biologics.

The Centre provides access to cutting edge training and research and is equipped with state-of-the-art lyophilization technology.


Lyostat 5 - Freeze-drying Microscope 

The Lyostat 5 from Biopharma Group is a freeze-drying microscope system which allows visualisation of formulation samples during lyophilisation. This allows for visual determination of critical formulation temperatures (See here). NIBRT use this instrument in training to facilitate understanding of critical process parameters in Lyophilisation and illustrate the criticality of formulation design and knowledge for successful lyophilisation cycle development.

Lyobeta Mini 

The Lyobeta Mini from Telstar is a 2-shelf bench-scale version of the Lyobeta 3PS. While the Lyobeta Mini at NIBRT does not have some of the features mentioned for the Lyobeta 3PS (e.g. pneumatic stoppering) it can still replicate many the same process cycle parameters used at industrial scale and is configured with an external condenser. Furthermore, the unit is run with Lyosuitelab 3.0 software, allowing easy transfer of operational knowledge, training and processes between both Lyobeta units. 

Lyobeta 3PS

The Lyobeta 3PS from Telstar is a 3-shelf pilot-scale lyophiliser with an external condenser and the ability to replicate many of the processes cycle parameters used at industrial scale. It also can perform controlled nucleation (LYONUC), pneumatic stoppering, shelf and product temperature monitoring as well as precise chamber pressure monitoring using a combination of Pirani and Capacitance probes. In addition, NIBRT also have a sample thief available for mid-cycle extraction of vial samples, useful for product and process development. The Lyosuitelab 3.0 software provides an easy interface for unit control, cycle design, data recording and interpretation.



Best Practices in Lyophilisation of Biologics and Vaccines

Event Type: Speaker & workshop event including expert speakers

Location: Onsite at NIBRT Facility, Dublin

When: 5th and 6th May 2022 - option to attend one or both days

Book Your Place: Click here

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