Careers - National Institute for Bioprocessing Research

Current Career Opportunities

VACANCY SUMMARY

POSITION AVAILABLE	E-Learning Content Developer
LOCATION	Dublin, Ireland
DEPARTMENT	Training Department
HIRING MANAGER	John Milne, Director of Training
CONTRACT TYPE	Permanent
SALARY & BENEFITS	Competitive salary and excellent suite of benefits. Benefits include: pension, private health insurance, income protection scheme, 25 days annual leave plus up to 3 additional company days off, generous training and career development supports, flexible working hours and work from home set up supported
APPLICATION DATE	Open for applications
INTERVIEW DATES	As soon as available (position to be filled as soon as possible)

ORGANISATION OVERVIEW

The National Institute for Bioprocessing Research and Training (‘NIBRT’) is a global centre of excellence, headquartered in Dublin that provides training and research solutions to the global biopharmaceutical manufacturing sector. NIBRT arose from an innovative collaboration between University College Dublin, Trinity College Dublin, Dublin City University and the Institute of Technology, Sligo, with core funding by the Government of Ireland through Ireland’s inward investment agency, IDA Ireland. NIBRT’s 6,500 M² facility has 90+ employees currently and houses fully operational pilot plants for biologics manufacturing training to industry and education as well as multiple research laboratories focussed on biopharmaceuticals manufacturing research.

ROLE PURPOSE

The NIBRT Online Academy (NOA) has grown significantly since its initial launch in January 2020. The platform delivers on demand learning on key aspects of biopharmaceutical manufacturing developed by leading industry experts. Users can access the modules online in their own time and study at their own pace. NOA provides a quality, efficient and cost-effective training solution from a recognised global leader in biopharmaceutical training. The interactive modules offer engaging multi-media content including video tutorials from subject matter experts, 3D models, animations and virtual simulations.

NIBRT wishes to appoint an E-Learning Content Developer to contribute to the continued successful implementation and future growth of NOA. The content developer will be responsible for the development and maintenance of key content for NOA, working directly with members of NIBRT’s Training team and associated commercial business units.

KEY RESPONSIBILITIES

Reporting to the Director of Training the key duties of the E-Learning Content Developer will include:

REQUIREMENTS

3-5 years’ experience in learning design and content development with clear experience in generating effective instructional text, audio and video scripts that support key learning objectives and strategy is essential for this role.
Detailed knowledge of leading online authoring and Learning Management Systems (Docebo^®learning suite) required.
Highly IT competent with detailed knowledge of digital content generation and management.
Preferable to hold a degree in related scientific field (Life Science/Biopharmaceutical Processing/Engineering) with relevant biopharmaceutical industry experience an advantage.
Excellent interpersonal skills both written and oral and ideally be an accomplished presenter.
Possess required job knowledge to successfully fulfil or exceed the requirements of the post.
The successful person will be a motivated self-starter, capable of working under their own initiative as part of a busy and dynamic training team.

ADDITIONAL IDEAL CRITERIA

Practical knowledge of biopharmaceuticals, mammalian cell culture and protein purification operations are desirable but not essential for this role.
The successful person will have previous experience of working in a third level training and or educational environment.

APPLICATION PROCESS

To apply for this position please forward your CV and cover letter to careers@nibrt.ie

Please include your name and the position which you are applying for in the subject line. Please note that the successful candidate may be required to supply parchments of degrees/qualifications/work permits. Informal enquiries can be made in confidence by contacting our Project Manager, Therese Keohane at careers@nibrt.ie

Bioprocessing Training Technician

VACANCY SUMMARY

POSITION AVAILABLE	Bioprocessing Training Technician
LOCATION	Dublin, Ireland
DEPARTMENT	Training Department
HIRING MANAGER	Shada Warreth, Training Resource Supervisor
CONTRACT TYPE	Fixed Term 12 Months
SALARY & BENEFITS	Competitive salary and excellent suite of benefits. Benefits include: pension, private health insurance, income protection scheme, 25 days annual leave plus up to 3 additional company days off, generous training and career development supports, flexible working hours and work from home set up supported
APPLICATION DATE	Open for applications
INTERVIEW DATES	As soon as available (position to be filled as soon as possible)

ORGANISATION OVERVIEW

The National Institute for Bioprocessing Research and Training (‘NIBRT’) is a global centre of excellence, headquartered in Dublin that provides training and research solutions to the global biopharmaceutical manufacturing sector. NIBRT arose from an innovative collaboration between University College Dublin, Trinity College Dublin, Dublin City University and the Institute of Technology, Sligo, with core funding by the Government of Ireland through Ireland’s inward investment agency, IDA Ireland. NIBRT’s 6,500 M² facility has 90+ employees currently and houses fully operational pilot plants for biologics manufacturing training to industry and education as well as multiple research laboratories focussed on biopharmaceuticals manufacturing research.

ROLE PURPOSE

NIBRT is a world-class institute that provides training and research solutions for the bioprocessing industry. Our mission is to support the bioprocessing industry by providing a unique learning experience for trainees in an environment that replicates the most modern industrial bioprocessing facility. The purpose of this role is to provide training and equipment support to the Training Team in the NIBRT bioprocessing plant and labs covering all areas including upstream, downstream, fill finish, QC, and support services.

KEY RESPONSIBILITIES

Day to day operation of laboratory and pilot plant equipment at NIBRT’s training facility.
Support training to include equipment and solution preparation pre and post use (upstream, downstream, fill finish, QC, Support)
Daily operations to include COP/SOP, autoclave, parts washer, solution preparation, cell culture
Implement and maintain documentation for the NIBRT Training (SOP’s, production batch records,) according to GMP/GDP requirements.
Control and organize ordering of lab and plant consumables
Assist with training and project work as required
Ensuring safe operation and maintenance of laboratory and plant equipment. Liaising with facilities team at NIBRT to resolve problems.
Any other reasonable duties as may be required from time to time by your line manager.

REQUIREMENTS

Hold a BSc or MSc in a related scientific field such as Life Sciences, Biopharmaceutical Processing, Engineering.
Knowledge of biopharmaceutical production operations and equipment.
Previous hands-on practical experience of mammalian cell culture would be a distinct advantage.
Previous hands-on practical experience of preparation of processing equipment including bioreactors, chromatography column packing, autoclaves, parts washers, COP, and SOP of stainless-steel vessels would be a distinct advantage.
Previous experience in a regulated industrial biopharmaceutical process environment would be a distinct advantage.
The successful technician will be a motivated self-starter, capable of working under their own initiative and as part of a busy training team.
High level of attention to detail and strong problem-solving skills required
Knowledge or experience of Delta V systems would be an advantage
Interest or knowledge of Biopharma 4.0 technology would be an advantage

APPLICATION PROCESS

To apply for this position please forward your CV and cover letter to careers@nibrt.ie

Please include your name and the position which you are applying for in the subject line. Please note that the successful candidate may be required to supply parchments of degrees/qualifications/work permits. Informal enquiries can be made in confidence by contacting our Project Manager, Therese Keohane at careers@nibrt.ie

Bioprocessing Trainer

VACANCY SUMMARY

POSITION AVAILABLE	Bioprocessing Trainer (multiple vacancies)
LOCATION	Dublin, Ireland
DEPARTMENT	Training Department
HIRING MANAGER	John Milne, Training Director
CONTRACT TYPE	Permanent Full-time position
SALARY & BENEFITS	Competitive salary and excellent suite of benefits. Benefits include: pension, private health insurance, income protection scheme, 25 days annual leave plus up to 3 additional company days off, generous training and career development supports, flexible working hours and work from home set up supported
APPLICATION DATE	Open for applications
INTERVIEW DATES	As soon as available (position to be filled as soon as possible)

ORGANISATION OVERVIEW

The National Institute for Bioprocessing Research and Training (‘NIBRT’) is a global centre of excellence, headquartered in Dublin that provides training and research solutions to the global biopharmaceutical manufacturing sector. NIBRT arose from an innovative collaboration between University College Dublin, Trinity College Dublin, Dublin City University and the Institute of Technology, Sligo, with core funding by the Government of Ireland through Ireland’s inward investment agency, IDA Ireland. NIBRT’s 6,500 M² facility has 90+ employees currently and houses fully operational pilot plants for biologics manufacturing training to industry and education as well as multiple research laboratories focussed on biopharmaceuticals manufacturing research.

WORKING IN NIBRT

Our dynamic and highly skilled training team strives for excellence in all that it does and achieves this through a culture of mutual support, collaborative learning, and dedication. Specific opportunities for professional growth include:

Unrivalled and broad-ranging experience in all aspects of the production, analysis, and regulation of the most advanced therapies on the market.
Upskilling through attendance of international conferences, training courses and further education.
Development of valuable transferrable skills such as oral and written communication, public speaking, project management and customer service.

Employees also enjoy additional benefits such as generous annual leave, flexi time and home working arrangements, support for further education, permanent health insurance and pension benefits.

ROLE PURPOSE

The purpose of this role is to develop and deliver training content to a wide variety of clients in the bioprocessing sector. The successful candidate will participate as a member of the NIBRT Training Team and will support the Training Director and Training Manager across all relevant areas.

DUTIES WILL INCLUDE:

Development and delivery of training material including lectures and practical content in biopharmaceutical processing operations.
Day to day operation of pilot plant facilities and laboratory equipment in NIBRT’s pilot production training facility.
Implementation and maintenance of documentation for the NIBRT facility and business activities (SOPs, production batch records, project proposals and technical reports).
Design, and delivery of customised training materials for clients onsite, online or offsite.
Measurement of training effectiveness using a variety of assessment tools.
Self-directed learning to ensure current knowledge of bioprocessing and an awareness of industry trends and advances.
Ensuring safe operation and maintenance of laboratory and plant equipment and liaising with facilities team at NIBRT to resolve problems.
Supporting NIBRT in the design and delivery of new and expanded methods of training (e.g. eLearning, blended learning etc.)
Hosting tours of NIBRT pilot production plant and attend business development meetings with prospective clients.
Represent the training department at company events (which may on occasion be during evenings or weekends).
Any other reasonable duties as may be required from time to time by your manager.

YOUR PROFILE:

You will hold a PhD in related scientific field (Life Science/Biopharmaceutical Processing/Engineering) OR a BSc/MSc in a related scientific field combined with relevant (bio) pharmaceutical industry experience.
Detailed practical knowledge of bioprocessing manufacturing operations is essential.
Documented interest, knowledge, or experience in one or more of the following is desired:
Cell and gene therapies
Vaccine manufacture
QC Microbiology
Sterile Fill Finish & aseptic processing of final drug product
Biopharma 4.0 technologies
Automation for Biopharma (DeltaV, LIMS etc.)
QC Bioanalytics
Drug Substance Manufacture

(Cover letter should clearly state which area applicant has knowledge/experience in)

Motivated self-starter, capable of working under their own initiative as part of a busy and dynamic training team.
Excellent interpersonal and verbal and written communication skills are essential for this role.

APPLICATION PROCESS

To apply for this position please forward your CV, cover letter and the names and contact details of two referees in a combined PDF document to NIBRT at careers@nibrt.ie, we are seeking to fill positions as soon as possible. Please include your name and ‘Bioprocessing Trainer vacancy’ in the subject line. (The successful candidate may be required to supply evidence of degrees/qualifications/work permits). Informal enquiries can be made by contacting our HR team at careers@nibrt.ie
Please note we are seeking a number of new trainers for the team!

#A

Characterisation Scientist: Downstream Clearance of Process Impurities (CCL Group)

VACANCY SUMMARY

POSITION AVAILABLE	Characterisation Scientist: Downstream Clearance of Process Impurities
LOCATION	NIBRT Facility, Dublin, Ireland
DEPARTMENT	CCL Group
HIRING MANAGER	Principal Investigator - Professor Jonathan Bones
CONTRACT TYPE	Fixed Term 12 Months
SALARY & BENEFITS	€45,000 - €50,000 commensurate with experience Benefits include: pension, private health insurance, income protection scheme, 25 days annual leave plus up to 3 additional company days off, generous training and career development supports, flexible working hours and work from home set up supported
APPLICATION DATE	Remains open until position(s) successfully filled
INTERVIEW DATES	Interviews will take place as quickly as possible

ORGANISATION OVERVIEW

The National Institute for Bioprocessing Research and Training (‘NIBRT’) is a global centre of excellence, headquartered in Dublin that provides training and research solutions to the global biopharmaceutical manufacturing sector. NIBRT arose from an innovative collaboration between University College Dublin, Trinity College Dublin, Dublin City University and the Institute of Technology, Sligo, with core funding by the Government of Ireland through Ireland’s inward investment agency, IDA Ireland. NIBRT’s 6,500 M² facility has 90+ employees currently and houses fully operational pilot plants for biologics manufacturing training to industry and education as well as multiple research laboratories focussed on biopharmaceuticals manufacturing research.

Project Summary

We develop and apply advanced analytical methods for biopharmaceutical characterisation based on our core competencies of liquid phase separations and high-resolution mass spectrometry to achieve our goal. We’re committed to working with our academic and industry collaborative research partners, whose mission aligns strongly with ours, to do excellent science and deliver real impact so that everyone benefits. If you want to do excellent science, if you’re dedicated and want to make an impact, then come join us.

As a member of the CCL team, you’ll be joining a project that is focused on understanding the behaviour and clearance of small molecule process impurities during downstream processing of antibodies. You’ll be meticulous in detail when performing such trace analysis and you’ll understand the importance of method performance and validation to ensure utmost confidence in your data. Your attention to detail will be second to none. You’ll take pride in your research and you’ll be motivated to publish and present your data to show the world what you’ve done.

Key Responsibilities:

Develop, validate and apply extraction techniques and analytical methods based on high resolution LC-MS, GC-MS and ICP-MS for ultratrace analysis of inorganic and organic contaminants in monoclonal antibody process streams.
Apply your in-depth chemistry knowledge to understand the behaviour of the analytes and develop models based on first principles to rationalise and predict their clearance during downstream processing.
Provide fast and accurate updates to internal stakeholders and collaborative partners so that everyone is sharing the journey.
Support and learn from collaborating scientists from our industrial partner to ensure that what you develop is directly applicable to address their requirements and aligns to their process needs.
Create and maintain high quality documentation and you’ll actively publish and present your research outputs.
Contribute to the on-going learning and success of the CCL team.

Requirements:

APPLICATION PROCESS

To apply for this position please forward your CV and cover letter to careers@nibrt.ie

Please include your name and the position which you are applying for in the subject line. Please note that the successful candidate may be required to supply parchments of degrees/qualifications/work permits. Informal enquiries can be made in confidence by contacting our Project Manager, Therese Keohane at careers@nibrt.ie

NIBRT is an Equal Opportunities Employer.

Lab Technician (CCL Group)

VACANCY SUMMARY

POSITION AVAILABLE	Lab Technician
LOCATION	NIBRT Facility, Dublin, Ireland
DEPARTMENT	CCL Group
HIRING MANAGER	Principal Investigator - Professor Jonathan Bones
CONTRACT TYPE	Fixed Term 12 Months
SALARY & BENEFITS	€28,000 - €31,000 commensurate with experience Benefits include: pension, private health insurance, income protection scheme, 25 days annual leave plus up to 3 additional company days off, generous training and career development supports, flexible working hours and work from home set up supported
APPLICATION DATE	Remains open until position(s) successfully filled
INTERVIEW DATES	Interviews will take place as quickly as possible

ORGANISATION OVERVIEW

The National Institute for Bioprocessing Research and Training (‘NIBRT’) is a global centre of excellence, headquartered in Dublin that provides training and research solutions to the global biopharmaceutical manufacturing sector. NIBRT arose from an innovative collaboration between University College Dublin, Trinity College Dublin, Dublin City University and the Institute of Technology, Sligo, with core funding by the Government of Ireland through Ireland’s inward investment agency, IDA Ireland. NIBRT’s 6,500 M² facility has 90+ employees currently and houses fully operational pilot plants for biologics manufacturing training to industry and education as well as multiple research laboratories focussed on biopharmaceuticals manufacturing research.

Project Summary

The Characterisation and Comparability Laboratory is a bioanalytical research group that uses its core competencies of liquid phase separations and high-resolution mass spectrometry to tackle wide ranging challenges in biopharmaceutical manufacture. We work with our academic and industry collaborative research partners, whose mission aligns strongly with ours, to do excellent science and deliver real impact so that everyone benefits. We’re seeking talented lab techs to support our activities and contribute to help us to achieve our research mission.

You’ll play a key role within the team and will be involved in diverse activities ranging from day-to-day operations within the lab, to instrument set up, calibration and routine maintenance, scheduling and liaison with performance maintenance service providers, performing routine analysis, assisting research staff in performing their experiments, inventory management and ensuring that protocols and documentation are kept up to date. You’ll have a passion for analytical science and the ability to work with state-of-the-art analytical instrumentation, many of which are the sole formats in the country, excites you. If so, we want to hear from you.

Key Responsibilities:

Standard lab operations including inventory management, ordering, update of protocols and documentation and ensuring that routine activities are performed as required in accordance with checklists or scheduled activities.
Routine maintenance of liquid chromatography and mass spectrometry instrumentation including system set up, calibration, cleaning and replacement of routine high wear and tear type components.
Scheduling and liaison with external instrument service providers and calibration agents to ensure instrument uptime while scheduling around the wider needs of the team.
Performing a variety of routine procedures such as protein purification, sample preparation and instrumental analysis using standard lab methods.
Working with researchers within the group to assist them with their experiments.
Contribute to the on-going learning and success of the CCL team.

Requirements:

You’ll have a passion for analytical and bioanalytical science and will have an understanding of liquid chromatography and mass spectrometry, in particular, for the analysis of proteins and biological materials.
You competent in the preparation of analytical solutions, standards and buffers, calculations in molarity, concentration and preparing dilutions are what you’re good at.
You’re organised, you know how to manage your time and have experience in prioritising activities while ensuring consistent delivery at an excellent standard.
You’re a standout teammate, you hold yourself and others accountable to results and you’re committed to achieve.
You’re a competent communicator who is well able to articulate their science using written and verbal English to specialist and non-specialist audiences.
You’re hardworking, you embrace challenges, you’re curious and ambitious, you’re driven by research and have a desire to learn.
You have excellent self-awareness and empathy, you can adapt and maintain focus and composure when research poses its challenges, especially when demands come from multiple sides.
You hold a NFQ recognised Level 7 qualification or higher in a discipline that makes you suitable for this challenge. Ideally, you’ll also have two years of experience in lab based positions or a similar role.

APPLICATION PROCESS

To apply for this position please forward your CV and cover letter to careers@nibrt.ie

Please include your name and the position which you are applying for in the subject line. Please note that the successful candidate may be required to supply parchments of degrees/qualifications/work permits. Informal enquiries can be made in confidence by contacting our Project Manager, Therese Keohane at careers@nibrt.ie

NIBRT is an Equal Opportunities Employer.

Research Associate - Downstream Clearance of Process Impurities (CCL Group)

VACANCY SUMMARY

POSITION AVAILABLE	Research Associate - Downstream Clearance of Process Impurities
LOCATION	NIBRT Facility, Dublin, Ireland
DEPARTMENT	CCL Group
HIRING MANAGER	Principal Investigator - Professor Jonathan Bones
CONTRACT TYPE	Fixed Term 12 Months
SALARY & BENEFITS	€32,000 - €35,000 commensurate with experience Benefits include: pension, private health insurance, income protection scheme, 25 days annual leave plus up to 3 additional company days off, generous training and career development supports, flexible working hours and work from home set up supported
APPLICATION DATE	Remains open until position(s) successfully filled
INTERVIEW DATES	Interviews will take place as quickly as possible

ORGANISATION OVERVIEW

The National Institute for Bioprocessing Research and Training (‘NIBRT’) is a global centre of excellence, headquartered in Dublin that provides training and research solutions to the global biopharmaceutical manufacturing sector. NIBRT arose from an innovative collaboration between University College Dublin, Trinity College Dublin, Dublin City University and the Institute of Technology, Sligo, with core funding by the Government of Ireland through Ireland’s inward investment agency, IDA Ireland. NIBRT’s 6,500 M² facility has 90+ employees currently and houses fully operational pilot plants for biologics manufacturing training to industry and education as well as multiple research laboratories focussed on biopharmaceuticals manufacturing research.

Project Summary

We develop and apply advanced analytical methods for biopharmaceutical characterisation based on our core competencies of liquid phase separations and high resolution mass spectrometry to achieve our goal. We’re committed to working with our academic and industry collaborative research partners, whose mission aligns strongly with ours, to do excellent science and deliver real impact so that everyone benefits. If you want to do excellent science, if you’re dedicated and want to make an impact, then come join us.

You’ll be joining the CCL team as part of an existing project. As a research associate, you’ll play a key role in carrying out all experimental aspects of the project, from experimental set up, to running ultrafiltration processes, to assisting with instrumental analysis and data processing. You’ll have a strong interest in analytical chemistry, particularly, trace analysis, forensics or environmental contaminant analysis and you’ll understand the complexity of these approaches. You’ll be a stickler for attention to detail, knowing how important it is for successful ultra-trace analysis. You’ll be committed, proud of what you do and a key team player.

Key Responsibilities:

Become a specialist in performing downstream processing of monoclonal antibodies, in particularly ultrafiltration and diafiltration at the lab scale.
Responsible for experimental preparation for all sample processing steps performed, working closely with and supporting the activities of the wider project team.
Assist with sample preparation, instrumental analysis using high resolution LC-MS, GC-MS and ICP-MS.
Provide fast and accurate updates to internal stakeholders and collaborative partners so that everyone is sharing the journey.
Support and learn from collaborating scientists from our industrial partner to ensure that what you develop is directly applicable to address their requirements and aligns to their process needs.
Create and maintain high quality documentation and you’ll actively publish and present your research outputs.
Contribute to the on-going learning and success of the CCL team.

Requirements:

You’ll understand what single use technologies for biopharmaceutical manufacturing are and the associated challenge posed by leachables from these disposable components.
You have excellent analytical lab skills, you’re organised and focused and understand the complexity of your actions and how they might affect trace analytical procedures.
Attention to detail is critical and you’re a stickler for this when in the lab.
You’re a versed communicator who is well able to articulate their science using written and verbal English to specialist and non-specialist audiences.
You’re hardworking, you embrace challenges and you’re motivated by the situations and environment that you find yourself in to do excellent research and deliver impactful science.
You’re curious and ambitious, you’re driven by research and have a desire to learn.
You have excellent self-awareness, you can adapt and maintain focus and composure when research poses its challenges.
You’re a standout teammate, you hold yourself and others accountable to results and you’re committed to achieve.
You hold a NFQ recognised Level 8 or 9 qualification with practical laboratory experience in a discipline that makes you suitable for this challenge.

APPLICATION PROCESS

To apply for this position please forward your CV and cover letter to careers@nibrt.ie

Please include your name and the position which you are applying for in the subject line. Please note that the successful candidate may be required to supply parchments of degrees/qualifications/work permits. Informal enquiries can be made in confidence by contacting our Project Manager, Therese Keohane at careers@nibrt.ie

NIBRT is an Equal Opportunities Employer.

Research Fellow (Cell Engineering Group)

VACANCY SUMMARY

Position Available: Research Fellow

Department: Cell Engineering

Hiring Manager: Niall Barron, PI

Contract Type: Fixed Term 2 Years

Location: GSK Belgium & NIBRT

Benefits: Benefits include: pension, private health insurance, income protection scheme, 25 days annual leave plus up to 3 additional company days off, generous training and career development supports, flexible working hours and work from home set up supported

Application Date: July 29th 2022

Interview Dates: End of July

About Us

The National Institute for Bioprocessing Research and Training (‘NIBRT’) is a global centre of excellence, headquartered in Dublin that provides training and research solutions to the global biopharmaceutical manufacturing sector. NIBRT’s 6,500 M² facility has 90+ employees currently and houses fully operational pilot plants for biologics manufacturing training to industry and education as well as multiple research laboratories focussed on biopharmaceuticals manufacturing research.

GSK is one of the world’s largest vaccines companies, delivering vaccines that help protect people at all stages of life. Its R&D focuses on developing vaccines against infectious diseases that combine high medical need and strong market potential.

GSK’s Vaccines business has a portfolio of more than 20 vaccines to help protect people from a range of diseases throughout their lives and the company supplies these vaccines to people living in over 160 countries.

Innovation is the beating heart of GSK’s business. Without it, there will be no new vaccines for the many diseases that still threaten individuals, families and communities around the world.

GSK’s Vaccines scientists work in three global R&D centres, in Belgium, Italy and the US. The company has long track record of collaborating with governments, healthcare providers, regulators, academic institutions, non-governmental organisations, vaccine producers and other key partners to tackle public health challenges around the world.

Project Summary

Chinese hamster ovary (CHO) cells are one of the most widely-used cell lines for recombinant protein production. A combination of in silico protein design, optimised expression vectors, stringent selection systems and optimised bioprocess conditions has meant high product yields with human-like glycosylation patterns are now routinely achieved. However, in some instances certain recombinant proteins are clipped or degraded during the production process, reducing yield and compromising the safety and the product potency, leading to an increase of manufacturing challenges. This project will focus on identifying the mechanism(s) causing the degradation of a small panel of recombinant vaccine antigens during expression in CHO cells and establishing strategies to prevent it. In particular it will employ a CRISPR knockout library to target genetic causes of this phenomenon. Building on the fundamental understanding of mechanisms leading to protein degradation we aim at generating a panel of novel parental CHO cell lines suitable for the production of clipping-prone proteins. This is an exciting collaboration between NIBRT and GSK and represents a unique opportunity for an ambitious postdoctoral scientist to spend time working on a highly applied scientifically challenging project. The successful candidate will have an opportunity to work in both NIBRT and GSK, splitting their time between the two locations.

Key Responsibilities:

Conducting a specific programme of research under the leadership of the Principal Investigators
Maintaining detailed and orderly records of the work performed, making them available to the Principal Investigator upon request
Disseminating the outcomes of this research at project meetings and through written reports
Preparing and presenting progress reports and research findings to colleagues for review purposes
Engaging in appropriate training and professional development opportunities as determined by the Principal Investigators
Carrying out any other duties within the scope, spirit and purpose of the job as requested by the Principal Investigators including routine lab management and maintenance duties

Requirements:

A PhD in molecular/cell biology or related discipline essential. Postdoctoral experience highly desirable.
Extent and breadth of experience in the following techniques in an academic or industrial environment will dictate level of appointment and salary;
- Experience in mammalian cell culture
- Experience with nucleic acid manipulation and analysis – cloning, qPCR, etc
- Some experience with gene/protein delivery methods – transfection, electroporation, viral transduction etc.
- Experience with targeted genetic engineering highly desirable, including CRISPR-based approaches and guide RNA design
Strong interest in applied research
Excellent writing and documentation skills
Effective oral and written communication skills: report writing, knowledge transfer and communication skills with the ability to present complex information effectively to a range of audiences

What we will offer you:

At NIBRT we believe that our role is to make a positive difference in everything that we do. Each of us has an important contribution to make and we’re committed to doing so in a way that drives equality in how we work, where we work and what we do.

We offer a competitive salary and an excellent benefits package, including health insurance, pension, and life assurance. Work/life balance is key to happy and motivated colleagues, and we offer 25 days annual leave plus up to 3 additional company days off.

We are committed to supporting and developing our team members through educational assistance. There’s also our professional EAP that’s there 24/7 if you ever need assistance or support.

NIBRT is committed to equal employment opportunities for all, we embrace difference and treat everyone with respect.

How To Apply

To apply for this position please forward your CV and cover letter to careers@nibrt.ie

Please include your name and the position which you are applying for in the subject line. Please note that the successful candidate may be required to supply parchments of degrees/qualifications/work permits. Informal enquiries can be made in confidence by contacting our Project Manager, Therese Keohane at careers@nibrt.ie

NIBRT is an Equal Opportunities Employer.

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_ga	2 years	The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors.
_gat_gtag_UA_151868507_1	1 minute	Set by Google to distinguish users.
_gat_gtag_UA_156611028_1	1 minute	Set by Google to distinguish users.
_gid	1 day	Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Some of the data that are collected include the number of visitors, their source, and the pages they visit anonymously.
CONSENT	2 years	YouTube sets this cookie via embedded youtube-videos and registers anonymous statistical data.
hubspotutk	5 months 27 days	HubSpot sets this cookie to keep track of the visitors to the website. This cookie is passed to HubSpot on form submission and used when deduplicating contacts.
vuid	2 years	Vimeo installs this cookie to collect tracking information by setting a unique ID to embed videos to the website.

Cookie	Duration	Description
test_cookie	15 minutes	The test_cookie is set by doubleclick.net and is used to determine if the user's browser supports cookies.
VISITOR_INFO1_LIVE	5 months 27 days	A cookie set by YouTube to measure bandwidth that determines whether the user gets the new or old player interface.
YSC	session	YSC cookie is set by Youtube and is used to track the views of embedded videos on Youtube pages.
yt-remote-connected-devices	never	YouTube sets this cookie to store the video preferences of the user using embedded YouTube video.
yt-remote-device-id	never	YouTube sets this cookie to store the video preferences of the user using embedded YouTube video.
yt.innertube::nextId	never	This cookie, set by YouTube, registers a unique ID to store data on what videos from YouTube the user has seen.
yt.innertube::requests	never	This cookie, set by YouTube, registers a unique ID to store data on what videos from YouTube the user has seen.

Cookie	Duration	Description
AnalyticsSyncHistory	1 month	No description
GoogleAdServingTest	session	No description
li_gc	2 years	No description
m	2 years	No description available.

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The multi-award winning National Institute for Bioprocessing Research and Training (NIBRT) is a global centre of excellence for training and research in bioprocessing. NIBRT offers a variety of careers in the areas of research, training and contract research.

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