Careers at NIBRT
The multi-award winning National Institute for Bioprocessing Research and Training (NIBRT) is a global centre of excellence for training and research in bioprocessing. NIBRT offers a variety of careers in the areas of research, training and contract research.
Current Career Opportunities
VACANCY SUMMARY
POSITION AVAILABLE
HR Specialist
LOCATION
NIBRT Facility, Dublin, Ireland (Hybrid/Flexible)
CONTRACT TYPE
Fixed Term 2 years
SALARY & BENEFITS
Benefits include: pension, private health insurance, income protection scheme, 25 days annual leave plus up to 3 additional company days off, generous training and career development supports, flexible working hours and work from home set up supported
APPLICATION DATE
Remains open until position successfully filled
INTERVIEW DATES
Interviews will take place as quickly as possible
ORGANISATION OVERVIEW
The National Institute for Bioprocessing Research and Training (‘NIBRT’) is a global centre of excellence, headquartered in Dublin that provides training and research solutions to the global biopharmaceutical manufacturing sector. NIBRT has over 100 of the most talented employees in the sector with ambitions to expand this number further in the next 5 years. NIBRT’s HR department is a key strategic partner in delivering an ambitious five-year business plan playing a central role in building and maintaining a respectful, enriching, and inclusive culture for all of NIBRT’s employees and students. NIBRT HR are current Award holders of both a Best Flexible Working Policy Award (HR Leadership & Management Awards 2022) and HR Achievement Award for innovative and flexible work practices (2022 Pharma Industry Awards). www.nibrt.ie #lifeatnibrt on LinkedIn
ROLE SUMMARY
Reporting to the Senior HR Specialist, the HR Specialist will play a critical role in delivering the employee experience required to retain our talented team. The HR Specialist in a hybrid capacity will be responsible for all HR administration for NIBRT and for supporting the Senior HR Specialist, HR Director, department Managers and staff on a range of people and culture projects and initiatives.
When asked in last year’s Employee Engagement survey, NIBRT employees rated their satisfaction with the existing HR team at 100%. The team are looking for an individual to join this team who is customer service oriented in their approach, who knows that every employee interaction, big or small, is an opportunity to influence their satisfaction with NIBRT. The team want someone with new ideas, willing to try new things, someone who seeks to understand other’s points of view, someone willing to challenge the status quo while at the same time, getting the basics right, paying attention to detail, treating every request with respect. The team have big ambitions with many proactive projects in the pipeline all of which the new HR Specialist will have the opportunity to contribute to and learn from.
KEY DUTIES & RESPONSIBILITIES
The key responsibilities of the job which can be done in a hybrid format include:
- Recruitment: Support NIBRT’s recruitment partner in commencing and closing various campaigns
- On-boarding: Responsible for employee and student on-boarding from contracting, hosting agreements, relocation, file set up and database maintenance, induction, and orientation
- People Processes: Responsible for the administration, tracking and monitoring of the following key people processes:
- Provide monthly HR payroll instruction to the Payroll Finance team
- Performance management
- Annual salary review
- Training and development
- Protected Leave
- Absence Management
- Time Management System including actioning critical contract dates
- Policies & Forms: Keep existing employment Policies, Templates and Policy Register up to date, developing new policies as appropriate, communicating changes and/or new policies to employees and support managers in implementing aforementioned policies and procedures
- Employee Support: Manage the HR Inbox on a daily basis answering queries promptly or escalating matters as required. Support managers and colleagues on operational HR and employee relations matters by providing professional and accurate advice and guidance.
- Benefits: Work with the Finance team to promote and administer employee benefits ensuring employees maximise the value of their remuneration packages with NIBRT.
- Health & Wellbeing: In conjunction with our Health Insurance partners, source and deliver annual health and wellbeing programme of events for employees. Actively support managers on all issues related to absence management, including occupational health services and monitoring compliance to the absence policy
- Training & Development: Responsible for agreeing the annual suite of general skills training for employees, scheduling and promoting the courses on offer and monitoring attendance and feedback.
- Internal Communications: Using our HubSpot platform, responsible for gathering, compiling content and publishing our bi-monthly employee newsletter.
- Leavers: Responsible for acknowledging resignations, managing exit process and conduct and track leaver statistics
- HR Projects: Lead and deliver various projects related to staff and improving services delivered by HR
- Other: Any other duties that may be reasonably required from time to time as requested by your Manager
CRITERIA
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- Appropriate 3rd Level qualification - essential
- Post qualification experience working in a modern HR Department - essential
- In-depth, up-to-date knowledge of employment law in Ireland – essential
- Positive and proactive attitude – responsive and service minded
- Ability to work on own initiative, remain organized and prioritise within own workload
- Adaptable approach, execution oriented and resilient
- Excellent written, numerical, reporting, and analytical skills
- Must have the ability to remain focused, professional, tactful, and discrete when handling sensitive and/or confidential information
- Experience supporting international candidates through VISA process and/or relocation would be welcomed
APPLICATION PROCESS
To apply for this position please forward your CV and cover letter to careers@nibrt.ie
Please include your name and the position which you are applying for in the subject line. Please note that the successful candidate may be required to supply parchments of degrees/qualifications/work permits. Informal enquiries can be made in confidence by contacting our Project Manager, Therese Keohane at careers@nibrt.ie
VACANCY SUMMARY
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POSITION AVAILABLE |
Director of Research & Innovation |
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LOCATION |
Dublin, Ireland |
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DEPARTMENT |
Research |
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HIRING MANAGER |
Darrin Morrissey, CEO |
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CONTRACT TYPE |
Permanent Full-Time position |
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APPLICATION DATE |
2nd December 2022 |
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INTERVIEW DATES |
Dec 2022 – Jan 2023 |
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ORGANISATION OVERVIEW
The National Institute for Bioprocessing Research and Training (‘NIBRT’) is a global centre of excellence, headquartered in Dublin that provides training and research solutions to the global biopharmaceutical manufacturing sector. NIBRT has over 100 of the most talented employees in the sector with ambitions to expand this number further in the next 5 years. NIBRT performs world class, industry-aligned research and training in all areas of biopharmaceutical manufacturing with the overarching aim of delivering practical solutions for the biopharma industry. A key objective of NIBRT’s research is to create innovation and drive better integration across all stages of biomanufacturing leading to improved productivity, reduced costs and more consistent quality of biological medicines and vaccines.
ROLE SUMMARY
Reporting to the NIBRT CEO, the Director of Research & Innovation will operate as the chief scientific officer of the organisation, leading the design and delivery of the NIBRT Research Strategic Plan, leading a team of NIBRT Principal Investigators and operating as a key member of the NIBRT Senior Leadership team.
The Director will also be responsible for:
- Leading the NIBRT Research Office in support of NIBRT’s research operations, ensuring the excellence of NIBRT’s research practices and operations and overseeing the performance of NIBRT Research.
- Ensuring NIBRT’s story as a research institute is communicated widely to external stakeholders.
- Ensuring that NIBRT stays constantly focused on the development of collaborative and strategic funding opportunities both with Industry and with national and international funding agencies.
DIRECT REPORTS
- Principal Investigators x 10+
- Associate Director of Research
KEY DUTIES & RESPONSIBILITIES
Strategy
- Responsible for the development and implementation of the NIBRT research strategy, as part of the broader NIBRT organisational strategy and 5-year business plan; working closely with the CEO, PI Team and SLT.
- Ensure NIBRT’s research strategy remains relevant and impactful to the global biopharmaceutical manufacturing industry’s growing needs, working closely with the Business Development and Training teams.
- Consult and confer with the NIBRT Scientific Advisory Board to get valuable independent guidance on future research direction, working with the CEO.
Operations
- Provide leadership to the NIBRT Research Office, which in turn:
- Supports all research operations at NIBRT
- Supports successful funding applications to the relevant research funding bodies.
- Drive recruitment of research talent
- Play a central role in senior PI recruitment and retention initiatives, working closely with HR.
- Develop talent search and identification strategies to ensure active pipeline of laboratory researchers, working with PIs, HR, and search firms.
- Accountable for the NIBRT research infrastructure plan. Work with PIs and Finance to ensure best utilisation of NIBRT’s CapEx resources.
Excellence
- Through the NIBRT Research Office, lead the improvement and maintenance of research practice standards across the institute, including strong compliance with national research policies and funder requirements.
- Work with the entire NIBRT Research team to establish and maintain a thriving NIBRT Research culture, founded on excellence and a stimulating and supportive environment allowing NIBRT to retain its HRS4R accreditation.
- Help to build NIBRT’s reputation through a range of outreach, communications and other appropriate initiatives.
Performance
- Provide leadership and mentoring to the NIBRT PI team to support the performance of their research operations and their teams.
- Manage and oversee the measurement of NIBRT Research outputs. Work closely with NIBRT Finance and the SLT to track and review the metric outcomes of the NIBRT Research group within the context of the 5-year business plan objectives.
Collaborations of scale
- Lead the NIBRT Research team and the wider organisation in identifying and targeting funding opportunities of scale. This will include national funding opportunities and international funding opportunities (such as Horizon Europe).
- Lead the NIBRT Research team in developing collaborations of scale with the biopharma manufacturing industry and build collaborative research networks with international consortia / member organisations.
Communications and Engagement
- Ensure excellent communication of NIBRT’s research outputs to academia, to industry, to government stakeholders and to the wider public, working very closely with the PI team, Research Office, Marketing/Comms team and CEO.
- Ensure that the NIBRT Research Culture is communicated and understood internally and externally.
- Build and maintain strong relationships between NIBRT and the main research funders nationally and internationally, i.e., SFI, Horizon 2020, Enterprise Ireland, etc.
- Build and maintain strong relationships and research partnerships between NIBRT and higher education institutes, nationally and internationally.
- Build and maintain NIBRT’s connectivity to the wider industry-based research community, in particular with corporate HQ research teams.
Key Performance Indicators
- NIBRT research growth as measured by a range of quantitative and qualitative metrics, including research outputs (e.g., publications, impact, both economic and societal, etc), successful grant applications, number of industry projects, funding revenues, IP created, technology transfers, international benchmarking, etc.
- Quality and number of research partnerships developed by NIBRT with higher education institutions and with industry.
SELECTION CRITERIA
Qualifications and Experience
- PhD in Life Science discipline, or equivalent.
- Senior management experience
- Research leadership experience
- Exemplary academic and/or industry track record and/or experience in operating at the interface.
Skills & Knowledge
- Strong managerial and leadership skills.
- Research background, ideally in bioprocessing, biopharmaceutical or aligned Life Science research.
- Strong working knowledge of the research landscape (performing, funding, public and private).
- Good understanding of the life cycle and challenges of biopharmaceutical manufacturing.
- Good insight into where the biopharma industry is headed and how it needs to develop.
Personal Characteristics
- Collaborative nature.
- Ability to connect with and mobilise support from many disparate groups inside and outside the workplace.
- Strong communicator.
- Diplomatic, but also firm and convincing.
APPLICATION PROCESS
To apply for this position please forward your CV and cover letter to careers@nibrt.ie
Please include your name and the position which you are applying for in the subject line. Please note that the successful candidate may be required to supply parchments of degrees/qualifications/work permits.
VACANCY SUMMARY
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POSITION AVAILABLE |
PhD Student (RNA Synthesis - FFP 2) |
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LOCATION |
Dublin, Ireland |
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DEPARTMENT |
Research |
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HIRING MANAGER |
Steven Ferguson |
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CONTRACT TYPE |
PhD Scholarship |
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APPLICATION DATE |
Open for applications |
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INTERVIEW DATES |
As soon as available (position to be filled as soon as possible) |
ORGANISATION OVERVIEW
The National Institute for Bioprocessing Research and Training (‘NIBRT’) is a global centre of excellence, headquartered in Dublin that provides training and research solutions to the global biopharmaceutical manufacturing sector. NIBRT arose from an innovative collaboration between University College Dublin, Trinity College Dublin, Dublin City University and the Institute of Technology, Sligo, with core funding by the Government of Ireland through Ireland’s inward investment agency, IDA Ireland. NIBRT’s 6,500 M² facility has 90+ employees currently and houses fully operational pilot plants for biologics manufacturing training to industry and education as well as multiple research laboratories focussed on biopharmaceuticals manufacturing research.
ROLE PURPOSE
mRNA vaccines are a promising approach to preventing infectious diseases and treating some forms of cancer, but they are remarkably unstable, requiring ultracold temperatures for shipping and storage. The broad goal of this research program is to develop innovative stabilization strategies for mRNA vaccines, grounded in a thorough understanding of mRNA degradation mechanisms and enabled by novel manufacturing methods.
The PhD Candidate will develop novel chemical synthesis and processing methods to synthesize chemically modified mRNA, representing a step change in the ability to tune mRNA for optimized therapeutic performance. The proposed methods also have the potential to greatly expand manufacturing capacity of RNA products globally. The position will also provide PhD candidate the opportunity to develop interdisciplinary skills crucial in drug development building on their underground background within an interdisciplinary team of chemists, pharmaceutical scientists, and chemical engineers in a field undergoing rapid scientific and commercial development.
The position is ideally suited to candidates with Batchelors or Masters Degrees in chemistry, medicinal chemistry, pharmaceutical sciences, chemical or biochemical engineering or closely related fields. The project is supported by a grant from Science Foundation Ireland. An honours degree (NFQ Level 8) is required, with enrolment requirements as per standard University College Dublin requirements.
The PhD student will enrol and receive a PhD degree on successful completion of their program from the Department of Chemical and Bioprocess Engineering at University College Dublin. They will report to the PI (Steven Ferguson) and will be assisted by postdoctoral scientists and others in the lab in collaboration with the research group of Prof. Elizabeth Topp.
This position is ideally suited to a researcher with a background in chemistry, biochemistry, chemical engineering, pharmaceutical chemistry, or related field.
KEY RESPONSIBILITIES
The key responsibilities of the job include:
- Conducting doctoral level research under the leadership of the Principal Investigator and/or senior postdoc;
- Maintaining detailed and orderly records of the work performed, making them available to the Principal Investigator and/or senior postdoc upon request;
- Disseminating the outcomes of this research in poster and/or podium presentations at regional, national, and international meetings and conferences;
- With collaborators and co-authors, generating manuscripts for publication in top-tier journals;
- Fulfilling all requirements of the grant and the host department;
- Participating fully in the wider research and scholarly activities of the group within the remit and restrictions of the appointed position;
- Carrying out any other duties within the scope, spirit and purpose of the job as requested by the Principal Investigator and/or senior postdoc;
- Complying with all NIBRT policies and regulations, including those in relation to Research Ethics and Health and Safety.
REQUIREMENTS
- A BSc in chemistry, biochemistry, chemical engineering, biochemical engineering, pharmaceutical chemistry, or a relevant related discipline from an approved degree awarding institution.
- Commitment to research excellence.
- Effective oral and written communication skills: report writing, knowledge transfer and communication skills with the ability to present complex information effectively to a range of audiences.
- Self-motivated and able to work collaboratively and as part of a team to an agreed work plan.
DESIRABLE CRITERIA
- Prior experience in an industrial or academic research laboratory.
- Experience in the biopharmaceutical industry and/or as an analytical chemist, g. quality control laboratories, industry, research.
- Experience working in multidisciplinary research teams.
TERMS
Subject to funding
APPLICATION PROCESS
To apply for this position please forward your CV and cover letter to careers@nibrt.ie
Please include your name and the position which you are applying for in the subject line. Please note that the successful candidate may be required to supply parchments of degrees/qualifications/work permits. Informal enquiries can be made in confidence by contacting our Project Manager, Therese Keohane at careers@nibrt.ie
VACANCY SUMMARY
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POSITION AVAILABLE |
PhD Student (Formulation & Stability - FFP) |
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LOCATION |
Dublin, Ireland |
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DEPARTMENT |
Formulation & Stability |
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HIRING MANAGER |
Elizabeth Topp |
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CONTRACT TYPE |
Fixed term |
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APPLICATION DATE |
Open for applications |
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INTERVIEW DATES |
As soon as available (position to be filled as soon as possible) |
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|
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ORGANISATION OVERVIEW
The National Institute for Bioprocessing Research and Training (‘NIBRT’) is a global centre of excellence, headquartered in Dublin that provides training and research solutions to the global biopharmaceutical manufacturing sector. NIBRT arose from an innovative collaboration between University College Dublin, Trinity College Dublin, Dublin City University and the Institute of Technology, Sligo, with core funding by the Government of Ireland through Ireland’s inward investment agency, IDA Ireland. NIBRT’s 6,500 M² facility has 90+ employees currently and houses fully operational pilot plants for biologics manufacturing training to industry and education as well as multiple research laboratories focussed on biopharmaceuticals manufacturing research.
ROLE PURPOSE
mRNA vaccines are a promising approach to preventing infectious diseases and treating some forms of cancer, but they are remarkably unstable, requiring ultracold temperatures for shipping and storage. The broad goal of this research program is to develop innovative stabilization strategies for mRNA vaccines, grounded in a thorough understanding of mRNA degradation mechanisms and enabled by novel manufacturing methods.
Over the last 30 years, the development of recombinant protein drugs has been supported by a vast literature that addresses the kinetics and mechanisms of protein degradation reactions. In contrast, very little is known about the factors controlling the chemical and physical stability of mRNA and mRNA lipid nanoparticles (mRNA LNP). This project will explore the mechanisms of mRNA degradation under formulation relevant conditions. This project will probe the mechanisms of chemical degradation of mRNA in aqueous solution, in mRNA LNP suspensions, and in dried solids. The effects of temperature, composition, pH, buffer and/or metal ion catalysis, will be among the factors explored. The physical stability of mRNA LNP will also be investigated by monitoring changes in particle size, particle size distribution, mRNA integrity, and encapsulation efficiency across a range of conditions. The results will begin to create a knowledge framework to support the rational design of mRNA LNP formulations and processes.
This position is ideally suited to a beginning graduate student researcher with a background in chemistry, biochemistry, chemical engineering, pharmaceutical chemistry, or related field. An understanding of basic biochemistry, particularly protein chemistry, would be highly advantageous. An honours degree (NFQ Level 8) is required. The project is supported by a grant from Science Foundation Ireland.
KEY RESPONSIBILITIES
- Conducting doctoral level research under the leadership of the Principal Investigator and/or senior postdoc;
- Maintaining detailed and orderly records of the work performed, making them available to the Principal Investigator and/or senior postdoc upon request;
- Disseminating the outcomes of this research in poster and/or podium presentations at regional, national, and international meetings and conferences;
- With collaborators and co-authors, generating manuscripts for publication in top-tier journals;
- Fulfilling all requirements of the host department;
- Participating fully in the wider research and scholarly activities of the group within the remit and restrictions of the appointed position;
- Carrying out any other duties within the scope, spirit and purpose of the job as requested by the Principal Investigator and/or senior postdoc;
- Complying with all NIBRT policies and regulations, including those in relation to Research Ethics and Health and Safety.
REQUIREMENTS
- A BSc in chemistry, biochemistry, chemical engineering, pharmaceutical chemistry, or a relevant related discipline from an approved degree awarding institution.
- Commitment to research excellence.
- Effective oral and written communication skills: report writing, knowledge transfer and communication skills with the ability to present complex information effectively to a range of audiences.
- Self-motivated and able to work collaboratively and as part of a team to an agreed work plan.
DESIRABLE CRITERIA
- Prior experience in an industrial or academic research laboratory.
- Experience in the biopharmaceutical industry and/or as an analytical chemist, e.g. quality control laboratories, industry, research.
- Experience working in multidisciplinary research teams.
TERMS
Subject to funding
APPLICATION PROCESS
To apply for this position please forward your CV and cover letter to careers@nibrt.ie
Please include your name and the position which you are applying for in the subject line. Please note that the successful candidate may be required to supply parchments of degrees/qualifications/work permits. Informal enquiries can be made in confidence by contacting our Project Manager, Therese Keohane at careers@nibrt.ie
VACANCY SUMMARY
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POSITION AVAILABLE |
Post Doc Researcher (Formulation and Stability) |
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LOCATION |
Dublin, Ireland |
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DEPARTMENT |
Formulation and Stability |
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HIRING MANAGER |
Elizabeth Topp |
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CONTRACT TYPE |
3 Years Fixed Term |
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SALARY & BENEFITS |
Competitive salary and excellent suite of benefits. Benefits include: pension, private health insurance, income protection scheme, 25 days annual leave plus up to 3 additional company days off, generous training and career development supports, flexible working hours and work from home set up supported |
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APPLICATION DATE |
Open for applications |
|
INTERVIEW DATES |
As soon as available (position to be filled as soon as possible) |
ORGANISATION OVERVIEW
The National Institute for Bioprocessing Research and Training (‘NIBRT’) is a global centre of excellence, headquartered in Dublin that provides training and research solutions to the global biopharmaceutical manufacturing sector. NIBRT arose from an innovative collaboration between University College Dublin, Trinity College Dublin, Dublin City University and the Institute of Technology, Sligo, with core funding by the Government of Ireland through Ireland’s inward investment agency, IDA Ireland. NIBRT’s 6,500 M² facility has 80 employees currently and houses fully operational pilot plants for biologics manufacturing training to industry and education as well as multiple research laboratories focussed on biopharmaceuticals manufacturing research.
ROLE SUMMARY
mRNA vaccines are a promising approach to preventing infectious diseases and treating some forms of cancer, but they are remarkably unstable, requiring ultracold temperatures for shipping and storage. The broad goal of this research program is to develop innovative stabilization strategies for mRNA vaccines, grounded in a thorough understanding of mRNA degradation mechanisms and enabled by novel manufacturing methods.
This project will explore the mechanisms of mRNA degradation under formulation relevant conditions, evaluating the effectiveness of chemical modifications in improving stability. In currently accepted solution-state mechanisms for mRNA degradation, the reaction occurs by intramolecular nucleophilic attack of the 2’OH of the ribose on the phosphorous atom of the phosphodiester bond. This suggests that chemical modifications that hinder this reaction may be stabilizing. However, current mechanisms have been established using di- and tri-nucleoside model compounds at elevated temperature; the mechanisms of degradation for full-length mRNA under formulation relevant conditions are not known.
This project will begin to address these deficiencies. The successful applicant for this postdoctoral position will develop analytical methods, perform stability studies, produce mRNA by IVT, perform post-transcriptional modifications, and conduct in vitro evaluation. The individual also will provide in-laboratory support for the Ph.D. students, prepare initial drafts of manuscripts and reports, give regular oral presentations of research progress, present research findings at meetings and conferences, and contribute to the overall management and upkeep of the laboratory. The project has considerable potential for generating intellectual property (IP) related to mRNA stabilization.
This position is targeted to an experienced postdoctoral researcher, holding an earned Ph.D. and having completed one or more years of postdoctoral research (SFI Level 2B). The position is ideally suited to candidates with doctoral degrees in chemistry, chemical engineering, pharmaceutical chemistry, or closely related fields, and with demonstrated expertise in the chemical analysis of biomolecules, chemical synthesis and/or nanoparticle production and characterization, as well as strong communication and interpersonal skills. Additional preferred qualifications include previous hands-on experience with mass spectrometry, capillary electrophoresis, ATR-FTIR, and/or LNP production and characterization, and/or statistical analysis and experimental design. An understanding of and previous experience with nucleotide synthesis would be highly advantageous. The project is supported by a grant from Science Foundation Ireland.
KEY RESPONSIBILITIES
- Conducting research in mRNA stability and chemical modification under the leadership of the Principal Investigator, including (but not limited to) preparation and characterization of mRNA and chemically modified mRNA, development of analytical methods, preparation and characterization of mRNA loaded lipid nanoparticles (LNP), and assessment of the translation of mRNA and chemically modified mRNA to protein using in vitro methods;
- Maintaining detailed and orderly records of the work performed, making them available to the Principal Investigator upon request;
- With the PI and NIBRT Research Office, ensuring timely reporting to the research sponsor (Science Foundation Ireland);
- Disseminating the outcomes of this research in poster and/or podium presentations at regional, national, and international meetings and conferences;
- Preparing manuscripts for publication in top-tier journals;
- Participating fully in the wider research and scholarly activities of the group within the remit and restrictions of the appointed position;
- Carrying out any other duties within the scope, spirit and purpose of the job as requested by the Principal Investigator;
- Complying with all NIBRT policies and regulations, including those in relation to Research Ethics and Health and Safety.
REQUIREMENTS
- An earned PhD in chemistry, chemical engineering, pharmaceutical chemistry, or a relevant related discipline from an approved degree awarding institution (essential).
- At least one year of relevant postdoctoral research experience.
- Commitment to research excellence (essential).
- Effective oral and written communication skills: report writing, knowledge transfer and communication skills with the ability to present complex information effectively to a range of audiences (essential).
- Self-motivated and able to work collaboratively and as part of a team to an agreed work plan (essential).
DESIRABLE CRITERIA
- Experience in the synthesis of chemically modified nucleosides and/or oligonucleotides.
- Experience in physicochemical analysis of nucleosides and/or oligonucleotides using methods such as NMR and mass spectrometry.
- Experience working in multidisciplinary research teams.
TERMS
Subject to funding.
APPLICATION PROCESS
To apply for this position please forward your CV and cover letter to careers@nibrt.ie
Please include your name and the position which you are applying for in the subject line. Please note that the successful candidate may be required to supply parchments of degrees/qualifications/work permits. Informal enquiries can be made in confidence by contacting our Project Manager, Therese Keohane at careers@nibrt.ie.
VACANCY SUMMARY
Position Available: Research Fellow
Department: Bioinformatics and Data Analysis Group
Hiring Manager: Dr Colin Clarke, PI Bioinformatics
Contract Type: Fixed Term 2 Years
Location: NIBRT Facility, Dublin, Ireland
Benefits: Benefits include: pension, private health insurance, income protection scheme, 25 days annual leave plus up to 3 additional company days off, generous training and career development supports, flexible working hours and work from home set up supported
Application Date: Open for applications
Interview Dates: October-November 2022
About Us
The National Institute for Bioprocessing Research and Training (‘NIBRT’) is a global centre of excellence, headquartered in Dublin that provides training and research solutions to the global biopharmaceutical manufacturing sector. NIBRT’s 6,500 M² facility has 90+ employees currently and houses fully operational pilot plants for biologics manufacturing training to industry and education as well as multiple research laboratories focussed on biopharmaceuticals manufacturing research.
PROJECT SUMMARY
Cell therapy is the transfer of intact, live cells into a patient to treat or cure a disease. Cell-based immunotherapy and in particular, modified-cell immunotherapy such as CAR-T, has been delivering spectacular results for cancer patients and is an entirely novel approach to treating cancer. Immune cells are removed from the patient’s blood and engineered to identify and attack the cancer cells when they are reintroduced into the patient.
NIBRT PI Dr Colin Clarke, is hiring a Bioinformatics Research Scientist funded for 2 years through under the Irish Government’s Disruptive Technology Innovation Fund (DTIF). The successful candidate will be joining a team focussed on understanding and optimising the CAR-T cell manufacturing process. The Bioinformatics Research fellow will play a key role in this project by analysing single cell RNA-seq, single nuclei ATAC-seq and single cell protein measurements from CAR-T cells. There will also be opportunities to contribute to the analysis of other exciting projects within NIBRT.
EXAMPLE PUBLICATIONS FROM THE CLARKE LABORATORY
- Tzani et al. Understanding the transcriptional response to ER stress in Chinese hamster ovary cells using multiplexed single cell RNA-seq. bioRxiv (2022).
- Castro-Rivadeneyra et. al. Found in translation: Microproteins are a new class of potential host cell impurity in mAb drug products. bioRxiv (2022).
- Charitidis et al. Monitoring CAR T cell generation with a CD8-targeted lentiviral vector by single-cell transcriptomics. Molecular Therapy (2021).
- Tzani et al. Tracing production instability in a clonally derived CHO cell line using single‐cell transcriptomics. Biotechnology and Bioengineering (2021).
DUTIES & RESPONSIBILITIES
- Conducting a specific programme of research under the leadership of the Principal Investigator
- Maintaining detailed and orderly records of the work performed, making them available to the Principal Investigator upon request
- Disseminating the outcomes of this research at project meetings and through written reports
- Preparing and presenting progress reports and research findings to colleagues for review purposes
- Engaging in appropriate training and professional development opportunities as determined by the Principal Investigator
- Carrying out any other duties within the scope, spirit and purpose of the job as requested by the Principal Investigator
ESSENTIAL & DESIRABLE CRITERIA
- A PhD in Bioinformatics or related discipline is essential.
- Experience working with Linux.
- Proficient in programming languages such as R and/or Python.
- Experience in the analysis next generation sequencing data is essential.
- Experience with a range of different data types is desirable (e.g., RNA-seq or ATAC-seq).
- Experience with single cell RNA-seq or single nuclei ATAC-seq data is highly desirable.
- Familiar with version control e.g., Git
- Excellent scientific writing skills
- Effective oral and written communication skills: report writing, knowledge transfer and communication skills with the ability to present complex information effectively to a range of audiences
How To Apply
To apply for this position please forward your CV, cover letter and the names and contact details of two referees in a combined PDF document to careers@nibrt.ie. Please include your name and the position for which you are applying for in the subject line. Please note that the successful candidate may be required to supply parchments of degrees/qualifications/work permits. Informal enquiries should be directed to Dr Colin Clarke (colin.clarke@nibrt.ie)
VACANCY SUMMARY
Position Available: Research Fellow
Department: Cell Engineering
Hiring Manager: Niall Barron, PI
Contract Type: Fixed Term 2 Years
Location: GSK Belgium & NIBRT
Benefits: Benefits include: pension, private health insurance, income protection scheme, 25 days annual leave plus up to 3 additional company days off, generous training and career development supports, flexible working hours and work from home set up supported
Application Date: Open for applications
Interview Dates: As soon as available (position to be filled as soon as possible)
About Us
The National Institute for Bioprocessing Research and Training (‘NIBRT’) is a global centre of excellence, headquartered in Dublin that provides training and research solutions to the global biopharmaceutical manufacturing sector. NIBRT’s 6,500 M² facility has 90+ employees currently and houses fully operational pilot plants for biologics manufacturing training to industry and education as well as multiple research laboratories focussed on biopharmaceuticals manufacturing research.
GSK is one of the world’s largest vaccines companies, delivering vaccines that help protect people at all stages of life. Its R&D focuses on developing vaccines against infectious diseases that combine high medical need and strong market potential.
GSK’s Vaccines business has a portfolio of more than 20 vaccines to help protect people from a range of diseases throughout their lives and the company supplies these vaccines to people living in over 160 countries.
Innovation is the beating heart of GSK’s business. Without it, there will be no new vaccines for the many diseases that still threaten individuals, families and communities around the world.
GSK’s Vaccines scientists work in three global R&D centres, in Belgium, Italy and the US. The company has long track record of collaborating with governments, healthcare providers, regulators, academic institutions, non-governmental organisations, vaccine producers and other key partners to tackle public health challenges around the world.
Project Summary
Chinese hamster ovary (CHO) cells are one of the most widely-used cell lines for recombinant protein production. A combination of in silico protein design, optimised expression vectors, stringent selection systems and optimised bioprocess conditions has meant high product yields with human-like glycosylation patterns are now routinely achieved. However, in some instances certain recombinant proteins are clipped or degraded during the production process, reducing yield and compromising the safety and the product potency, leading to an increase of manufacturing challenges. This project will focus on identifying the mechanism(s) causing the degradation of a small panel of recombinant vaccine antigens during expression in CHO cells and establishing strategies to prevent it. In particular it will employ a CRISPR knockout library to target genetic causes of this phenomenon. Building on the fundamental understanding of mechanisms leading to protein degradation we aim at generating a panel of novel parental CHO cell lines suitable for the production of clipping-prone proteins. This is an exciting collaboration between NIBRT and GSK and represents a unique opportunity for an ambitious postdoctoral scientist to spend time working on a highly applied scientifically challenging project. The successful candidate will have an opportunity to work in both NIBRT and GSK, splitting their time between the two locations.
Key Responsibilities:
- Conducting a specific programme of research under the leadership of the Principal Investigators
- Maintaining detailed and orderly records of the work performed, making them available to the Principal Investigator upon request
- Disseminating the outcomes of this research at project meetings and through written reports
- Preparing and presenting progress reports and research findings to colleagues for review purposes
- Engaging in appropriate training and professional development opportunities as determined by the Principal Investigators
- Carrying out any other duties within the scope, spirit and purpose of the job as requested by the Principal Investigators including routine lab management and maintenance duties
Requirements:
- A PhD in molecular/cell biology or related discipline essential. Postdoctoral experience highly desirable.
- Extent and breadth of experience in the following techniques in an academic or industrial environment will dictate level of appointment and salary;
- Experience in mammalian cell culture
- Experience with nucleic acid manipulation and analysis – cloning, qPCR, etc
- Some experience with gene/protein delivery methods – transfection, electroporation, viral transduction etc.
- Experience with targeted genetic engineering highly desirable, including CRISPR-based approaches and guide RNA design
- Strong interest in applied research
- Excellent writing and documentation skills
- Effective oral and written communication skills: report writing, knowledge transfer and communication skills with the ability to present complex information effectively to a range of audiences
What we will offer you:
At NIBRT we believe that our role is to make a positive difference in everything that we do. Each of us has an important contribution to make and we’re committed to doing so in a way that drives equality in how we work, where we work and what we do.
We offer a competitive salary and an excellent benefits package, including health insurance, pension, and life assurance. Work/life balance is key to happy and motivated colleagues, and we offer 25 days annual leave plus up to 3 additional company days off.
We are committed to supporting and developing our team members through educational assistance. There’s also our professional EAP that’s there 24/7 if you ever need assistance or support.
NIBRT is committed to equal employment opportunities for all, we embrace difference and treat everyone with respect.
How To Apply
To apply for this position please forward your CV and cover letter to careers@nibrt.ie
Please include your name and the position which you are applying for in the subject line. Please note that the successful candidate may be required to supply parchments of degrees/qualifications/work permits. Informal enquiries can be made in confidence by contacting our Project Manager, Therese Keohane at careers@nibrt.ie
NIBRT is an Equal Opportunities Employer.
VACANCY SUMMARY
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POSITION AVAILABLE |
Research Communication and Outreach Officer |
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LOCATION |
Dublin, Ireland (Hybrid) |
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DEPARTMENT |
Research Office |
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HIRING MANAGER |
Jennifer Byrne, Associate Director of Research |
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CONTRACT TYPE |
Permanent |
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SALARY & BENEFITS |
Competitive salary and excellent suite of benefits. Benefits include: pension, private health insurance, income protection scheme, 25 days annual leave plus up to 3 additional company days off, generous training and career development supports, flexible working hours and work from home set up supported |
|
APPLICATION DATE |
Open for applications |
|
INTERVIEW DATES |
As soon as available (position to be filled as soon as possible) |
ORGANISATION OVERVIEW
The National Institute for Bioprocessing Research and Training (‘NIBRT’) is a global centre of excellence, headquartered in Dublin that provides training and research solutions to the global biopharmaceutical manufacturing sector. NIBRT arose from an innovative collaboration between University College Dublin, Trinity College Dublin, Dublin City University and the Institute of Technology, Sligo, with core funding by the Government of Ireland through Ireland’s inward investment agency, IDA Ireland. NIBRT’s 6,500 M² facility has 90+ employees currently and houses fully operational pilot plants for biologics manufacturing training to industry and education as well as multiple research laboratories focussed on biopharmaceuticals manufacturing research.
ROLE PURPOSE
The National Institute for Bioprocessing Research and Training (NIBRT) is seeking candidates for the post of Research Communications and Outreach Officer. This role will be based within the NIBRT Research Office.
The NIBRT Research Office supports NIBRT researchers in applying for funding under national and international funding programmes as well as through direct funding from industry partners.
The NIBRT Research Office plays a key role in supporting NIBRT researchers in the management of their funded research activities. In order to support wider dissemination and promotion of the high-quality research ongoing in NIBRT, the Research Office has created a new role focused on Research Communication and Outreach.
We are seeking a scientifically literate, motivated, and effective communicator who will spearhead the development and delivery of the NIBRT Research Team’s communication activities. The successful candidate will be expected to have a good working knowledge of the scientific areas underpinning research in the manufacture of biopharmaceuticals and be willing to learn more about biopharmaceutical manufacturing research. The successful candidate will be instrumental in growing and developing the profile of the organisation and support the delivery of research output and information across a variety of communication channels. This will include the maintenance of websites, social media and other digital communications related to NIBRT research.
KEY RESPONSIBILITIES
- To regularly disseminate information relating to NIBRT research activities through a variety of channels, online or otherwise
- To contribute to and engage with members of the NIBRT Research Team including Principal Investigators (PIs), Post-Doctoral Researchers, postgraduate students, Research Assistants and members of the Research Office in the development of new outreach/communication opportunities, including taking a lead role in the development of creative materials and resources such as educational resources, information graphics and publications.
- Provide public engagement and outreach expertise, knowledge, and specialist input into research proposals developed by NIBRT PIs and researchers.
- To liaise with the NIBRT Marketing Manager to maintain and update resources on-line, including the NIBRT Research website, social media platforms and digital communications.
- To plan, develop and deliver an agreed annual programme of Communications and Outreach activities and events for the NIBRT Research team, with key partners and stakeholders as appropriate.
- To organise, co-ordinate and support the delivery of key research-focused engagement events such as conferences, seminars, workshops and training events.
- With other Research Office team members, assist with the management of the NIBRT research output log including the collation and production of relevant data required for reporting to stakeholders or for NIBRT publications (e.g. NIBRT’s Annual Report);
- To support NIBRT’s Research Office, Chief Scientific Officer and Chief Executive Officer in the provision of key communications metrics to assess the reach and impact of the organisation and its outreach activities.
- To support NIBRT with current outreach activities such as the NIBRT Transition Year programme
- To support NIBRT as an organisation in the development of submissions for awards or other measures of esteem.
- To develop and maintain key partnerships with external stakeholders such as research collaborators and partners, State agencies and sectoral stakeholders for the dissemination of information and to maximise publicity about the work of the NIBRT Research team.
- If appropriate, apply for funding to support specific outreach activities or collaborate with others on such applications (e.g. via the SFI Discover Programme)
- Any other duties as may be reasonably required from time to time in respect of this post.
ESSENTIAL CRITERIA
NIBRT is seeking a driven individual who is highly motivated, focused upon results and has a passion for discussing and disseminating research to fulfil this role.
To qualify, you must have:
- Research skills/education to Masters level in a subject relevant to the post.
- Minimum 2 years of experience of research communication activities, to include both of the areas of essential experience outlined below:
- At least 6 months experience of formulating, delivering, and evaluating public outreach, education or communication activities ideally relating to biomedical or bio/pharmaceutical science
- At least 6 months experience of managing and delivering public outreach and communication through the use of digital platforms including management of websites, social media platforms and digital communications. - Excellent interpersonal/communication skills and an ability to work effectively with research team members, management, and other stakeholders across all levels, both internally and externally.
- Ability to manage a varied and demanding schedule of priorities.
- Ability to work on own initiative and within tight deadlines.
- Ability to think creatively and independently.
- Ability to develop new skills as may be required by the role.
DESIRABLE CRITERIA
- A PhD Degree in a discipline closely related to the post
- Project management skills/qualification would be desirable.
REQUIRED SKILLS & COMPETENCIES
- Excellent written and verbal communication skills.
- Excellent practical skills in the delivery of Communications and Outreach activities.
- Strong organisation and time management skills.
- Sound academic and professional knowledge about Communications and Outreach involving areas of research encompassed by the NIBRT Research team (for example, analytical chemistry, biomedical research, proteomics, genomics, manufacturing).
- Accuracy and attention to detail essential.
- Strong interpersonal skills and ability to work well with others including a wide range of audiences that include specialist practitioners and general interest groups.
- Ability to prioritise workload.
- Flexibility and adaptability in the context of remote working arrangements.
APPLICATION PROCESS
To apply for this position please forward your CV and cover letter to careers@nibrt.ie
Please include your name and the position which you are applying for in the subject line. Please note that the successful candidate may be required to supply parchments of degrees/qualifications/work permits.
Informal enquiries can be made in confidence by contacting our Associate Director of Research, Jennifer Byrne at jennifer.byrne@nibrt.ie
VACANCY SUMMARY
|
POSITION AVAILABLE |
Bioprocessing Trainer (multiple vacancies) |
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LOCATION |
Dublin, Ireland |
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DEPARTMENT |
Training Department |
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HIRING MANAGER |
John Milne, Training Director |
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CONTRACT TYPE |
Permanent Full-time position |
|
SALARY & BENEFITS |
Competitive salary and excellent suite of benefits. Benefits include: pension, private health insurance, income protection scheme, 25 days annual leave plus up to 3 additional company days off, generous training and career development supports, flexible working hours and work from home set up supported |
|
APPLICATION DATE |
Open for applications |
|
INTERVIEW DATES |
As soon as available (position to be filled as soon as possible) |
ORGANISATION OVERVIEW
The National Institute for Bioprocessing Research and Training (‘NIBRT’) is a global centre of excellence, headquartered in Dublin that provides training and research solutions to the global biopharmaceutical manufacturing sector. NIBRT arose from an innovative collaboration between University College Dublin, Trinity College Dublin, Dublin City University and the Institute of Technology, Sligo, with core funding by the Government of Ireland through Ireland’s inward investment agency, IDA Ireland. NIBRT’s 6,500 M² facility has 90+ employees currently and houses fully operational pilot plants for biologics manufacturing training to industry and education as well as multiple research laboratories focussed on biopharmaceuticals manufacturing research.
WORKING IN NIBRT
Our dynamic and highly skilled training team strives for excellence in all that it does and achieves this through a culture of mutual support, collaborative learning, and dedication. Specific opportunities for professional growth include:
- Unrivalled and broad-ranging experience in all aspects of the production, analysis, and regulation of the most advanced therapies on the market.
- Upskilling through attendance of international conferences, training courses and further education.
- Development of valuable transferrable skills such as oral and written communication, public speaking, project management and customer service.
Employees also enjoy additional benefits such as generous annual leave, flexi time and home working arrangements, support for further education, permanent health insurance and pension benefits.
ROLE PURPOSE
The purpose of this role is to develop and deliver training content to a wide variety of clients in the bioprocessing sector. The successful candidate will participate as a member of the NIBRT Training Team and will support the Training Director and Training Manager across all relevant areas.
DUTIES WILL INCLUDE:
- Development and delivery of training material including lectures and practical content in biopharmaceutical processing operations.
- Day to day operation of pilot plant facilities and laboratory equipment in NIBRT’s pilot production training facility.
- Implementation and maintenance of documentation for the NIBRT facility and business activities (SOPs, production batch records, project proposals and technical reports).
- Design, and delivery of customised training materials for clients onsite, online or offsite.
- Measurement of training effectiveness using a variety of assessment tools.
- Self-directed learning to ensure current knowledge of bioprocessing and an awareness of industry trends and advances.
- Ensuring safe operation and maintenance of laboratory and plant equipment and liaising with facilities team at NIBRT to resolve problems.
- Supporting NIBRT in the design and delivery of new and expanded methods of training (e.g. eLearning, blended learning etc.)
- Hosting tours of NIBRT pilot production plant and attend business development meetings with prospective clients.
- Represent the training department at company events (which may on occasion be during evenings or weekends).
- Any other reasonable duties as may be required from time to time by your manager.
YOUR PROFILE:
- You will hold a PhD in related scientific field (Life Science/Biopharmaceutical Processing/Engineering) OR a BSc/MSc in a related scientific field combined with relevant (bio) pharmaceutical industry experience.
- Detailed practical knowledge of bioprocessing manufacturing operations is essential.
- Documented interest, knowledge, or experience in one or more of the following is desired:
- Cell and gene therapies
- Vaccine manufacture
- QC Microbiology
- Sterile Fill Finish & aseptic processing of final drug product
- Biopharma 4.0 technologies
- Automation for Biopharma (DeltaV, LIMS etc.)
- QC Bioanalytics
- Drug Substance Manufacture
(Cover letter should clearly state which area applicant has knowledge/experience in)
- Motivated self-starter, capable of working under their own initiative as part of a busy and dynamic training team.
- Excellent interpersonal and verbal and written communication skills are essential for this role.
APPLICATION PROCESS
- To apply for this position please forward your CV, cover letter and the names and contact details of two referees in a combined PDF document to NIBRT at careers@nibrt.ie, we are seeking to fill positions as soon as possible. Please include your name and ‘Bioprocessing Trainer vacancy’ in the subject line. (The successful candidate may be required to supply evidence of degrees/qualifications/work permits). Informal enquiries can be made by contacting our HR team at careers@nibrt.ie
- Please note we are seeking a number of new trainers for the team!
#A
NIBRT does not accept unsolicited resumes from agencies and/or search firms for any job posted on this or a referring site. Without a valid signed search agreement in place for the position listed, NIBRT will not pay a fee to the agency or search firm in the event that a candidate is hired for a position as a result of an unsolicited agency or search firm referral.
NIBRT Employee Benefits
35 Hour Week
35 hours per week, Monday to Friday
Annual Leave
25 days per year, plus up to 3 company days
Pension
Defined contribution (5%) pension scheme
Health Insurance
NIBRT pay your health insurance plan
Life Insurance
Death in Service Life Assurance cover
Education
Education assistance, paid study time
Flexitime
Flexi start & finish times outside of core hours
Work From Home
Excellent work remotely supports inc. office fit out
Tax Savers
Travel Saver Tickets / Bike to work scheme
EAP
Extensive LAYA Employee Assistance Scheme
Our Values at NIBRT
Collaboration
Innovation
Respect
Client Focus
Learning Organisation
Excellence
Safety
A Day In The Life of a NIBRT Employee
Stephen McCann
What is a typical day in the life like for a NIBRT team member?
As a technician in NIBRT, my day-to-day activities are varied and engaging. No day is the same in NIBRT. There is always work to be found with many projects available to dip into.
The work covers all areas of the biopharmaceutical industry. In one day, I can set-up a stainless-steel bioreactor, run a clean-in-place cycle on a chromatography column, and troubleshoot problems with a restricted access barrier system. This is not to mention preparing reagents for the operation of analytical equipment like a spectrophotometer or UPLC machine.
The range of equipment I operate and maintain covers a large range. In the area of upstream alone, I have worked on old autoclavable bioreactors to more state-of-the-art wave bag bioreactors for cell and gene therapy. New pieces of equipment are bought regularly and afford me a great opportunity to engage with equipment at different levels. We have recently got a new in-line dilution skid which I have performed an SAT on, along with the development of its operating parameters and its use.
This work allows me to challenge myself on a day-to-day basis alongside working with a team that is always striving for better. Your voice matters in the training team in NIBRT, with a large degree of autonomy granted for you to get your work done in a manner that best befits the team and its goals. This has led to me being very happy in my current role and looking forward to what the future has to offer for NIBRT.
Adam Bergin
What is a typical day in the life like for a NIBRT team member?
There is never a “typical” work day in my role as a PhD student. This is what I like most about what I do; I am always trying to think of unique experiments as part of my research. I have been in NIBRT for three years, and I can honestly say that my experience so far have been a pleasure. My colleagues in the CTG lab are always supportive of my goals and advise me on the best course of action. I enjoy a balance of conducting wet lab work in NIBRT, but also availing of the facilities that are available to me as a UCD student. Everything I need is at my doorstep.
My project requires me to perform bench scale cell culture work, with the ultimate goal of monitoring cell viability in bioreactors using novel analytical technologies. I have access to modern and well-maintained equipment that allows my research to flourish. The research team in NIBRT is a tight-knit group, which is particularly useful during my PhD studies as I have access to a wealth of knowledge and experience. There are frequent seminars and spotlight sessions within NIBRT to keep us up to date on our newest findings.
Ultimately the experiments I perform allow me the opportunity to speak at conferences and publish articles. So far during my time in NIBRT, I have travelled to the United States and Denmark to speak at globally recognizes society meetings. Now that my four years are coming to a close, I look forward to concluding my lab work and submitting my final thesis. I would recommend NIBRT wholeheartedly to anybody who has the opportunity to join our team.
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NIBRT is delighted to have won ‘Best Flexible Working Strategy’ for our hybrid working model. NIBRT has spent two years designing and implementing our pandemic and post pandemic responses to hybrid working and implemented a persona driven model with varying flexibilities for different roles. Launched in 2015, the HR Leadership & Management Awards has established itself as the benchmark for those demonstrating excellence in HR in Ireland.
NIBRT has received the "HR Excellence in Research" designation, identifying NIBRT as a provider of a high standard working environment for researchers. This award recognises NIBRT’s equitable recruitment and appraisal procedures and its commitment to implement the principles of 40 Principles of Charter and Code 2005 Conduct for the Recruitment of Researchers (the Charter and Code).
NIBRT is delighted to have been awarded Investors in Diversity Silver accreditation from the Irish Centre for Diversity in recognition of our commitment to a diverse and equal workplace. Investors in Diversity Silver affirms that a business has been benchmarked against other bodies and has both embedded inclusive practices throughout the organisation as well as developed and fostered a sense of fairness and belonging among colleagues.
