Careers at NIBRT
We are now hiring for the below positions
Current Career Opportunities
There is very significant interest in Gene Therapy approaches to disease treatment currently. Adeno-associated virus (AAV)-based gene therapies represent an exciting new wave of advanced therapy medicinal products (ATMPs) that are being generated for the treatment of ailments caused by a defective gene within certain patient populations. AAV based gene therapy is used to deliver a correctly functioning copy of the gene to the patient. Very promising results have been reported in a number of genetic diseases including haemophilia and ocular degeneration.
However, current yields of AAV from the manufacturing process mean that supplying patients with the required quantities of medicine will be challenging.
This project – a collaboration between NIBRT and Allergan Biologics – will address the following challenges in AAV production:
- To optimise a cell culture process for generation of infectious AAV particles of various serotypes
- To establish vectors and transfection/transduction conditions to minimise incorrect packaging events
- To investigate sensitive analytical methods for the characterisation of the resulting AAV particles that enable differentiation between full and empty AAV capsids
NIBRT is hiring two Research Fellows and two Postdoctoral Scientists to address these areas of interest.
Further information available Gene Therapy Vacancies.
The Company
The National Institute for Bioprocessing Research and Training (NIBRT) is a global centre of excellence for training and research in biopharmaceutical manufacturing.
NIBRT is located in a world-class facility in County Dublin, Ireland. This facility is purpose-built to closely replicate a modern bioprocessing plant with state-of the art equipment and enables NIBRT to offer the highest quality training and research solutions.
For more information and insight in to working at NIBRT, please visit our website www.nibrt.ie
The Department
The Systems Biology and Data Analytics (SBDA) focuses on two major avenues of research:
- Improving bioprocess monitoring, performance, automation, and yields through Machine Learning (ML) techniques and Big Data analytics, incorporating large historical data sets as well as real-time sensor data
- Furthering our understanding of CHO (Chinese hamster ovary) cell biology through the application of multi-omics techniques, with a particular focus on next-generation sequencing
The Position
Role Overview
We are looking for a graduate-level data scientist / software developer interested in analysing and presenting data to the user in an easy-to-understand fashion. The ideal candidate will have experience with multivariate statistics, Machine Learning (ML) algorithms, and Big Data analytics, and / or experience within the biopharmaceutical industry.
NIBRT has partnered with Siemens to deliver cutting-edge software for analysis and predictive modelling of bioprocess data, as well as automated replication and optimization of individual product batches or entire production lines. This NIBRT-Siemens bioMac collaboration will develop the analysis software in question and test it with biopharmaceutical industry partners.
The collaboration was recognised at the Irish Pharma Awards 2019 winning an award for Project of the Year (https://www.pharmaawards.ie/2019-winners).
Job Functions
- Manage a specific programme of research under the leadership of the Principal Investigator and/or Project Manager and disseminate the outcomes of this research at project meetings through written reports for internal and external stakeholders
- Liaise with all project partners/stakeholders and relevant industries where necessary
- Engage in appropriate training and professional development opportunities as determined by the Principal Investigator and/or Project Manager
- Prepare and present progress reports and research findings to colleagues for review purposes
- Responsible for undertaking all assigned programming tasks including maintaining coherent and detailed code documentation
- Participate fully in the wider research and scholarly activities of the Institute within the remit and restrictions of the appointed position
- Carry out any other duties within the scope, spirit and purpose of the job as requested by the line manager
- Comply with all NIBRT policies and regulations, including those in relation to Research Ethics and Health and Safety
Requirements
Essential
- A Bachelor’s degree in computer science, mathematics, physics, chemistry, biology, engineering, or a relevant, related discipline from an approved degree-awarding institution
- Strong R-language programming skills, familiarity with Shiny and Shinydashboard
- Experience with the Git versioning system as well as GitHub / GitLab
- Prior experience in exploratory data analysis and predictive modelling
- Experience with distributed computing and file systems (Apache Hadoop and Spark)
- Commitment to research excellence, clean coding techniques
- Demonstrable ability to adapt to change, including but not limited to: quickly learning new programming languages and analysis techniques, responding to and addressing client concerns
- Effective note-keeping, report writing, knowledge transfer and communication skills with the ability to present complex information effectively to a range of audiences
- Self-motivated with the ability to work collaboratively and as part of a team and to stick to an agreed work plan
Desirable
- Familiarity with HTML / CSS / JavaScript and other web development technologies
- Experience implementing ML algorithms
- Experience writing commercial software
- Experience within the biopharmaceutical industry or a demonstrable understanding of biomanufacturing processes; statistical analysis of bioprocessing data
- Experience of working in multidisciplinary research teams
- Project administration skills
Terms and Conditions of Employment
This is a 12-month, fixed-term contract of employment, with a possibility for an extension
- Salary commensurate on experience
- You must be eligible to work in Ireland to apply for this position
How to Apply:
To apply for this position please forward your CV, cover letter and the names and contact details of three referees in a combined PDF document to NIBRT HR department at careers@nibrt.ie. Please include your name and the position for which you are applying – Data Scientist Ref: DS11/2019 - in the subject line. Please note that the successful candidate may be required to supply parchments of degrees / qualifications.
Closing date: 5pm on Friday, 29th November 2019
For more information about the role, please contact colin.clarke@nibrt.ie
NIBRT is an equal opportunities employer.
The Company
The National Institute for Bioprocessing Research and Training (NIBRT) is a global centre of excellence for training and research in biopharmaceutical manufacturing. NIBRT is located in a world-class facility in County Dublin, Ireland. This facility is purpose-built to closely replicate a modern bioprocessing plant with state-of the art equipment and enables NIBRT to offer the highest quality training and research solutions.
For more information and insight in to working at NIBRT, please visit our website www.nibrt.ie
The Department:
NIBRT is a world-class institute that provides training and research solutions for the bioprocessing industry. Our mission is to support the bioprocessing industry by providing a unique learning experience for trainees in an environment that replicates the most modern industrial bioprocessing facility.
The Role:
The purpose of this role is to provide training and equipment support to the Training Team in the NIBRT bioprocessing plant and labs covering all areas including upstream, downstream, fill finish and support services.
Duties of the Bioprocessing technician will include:
- Day to day operation of pilot plant facilities and laboratory equipment to maintain a centre of excellence in the Training Department
- Weekly cell culture activities to prepare cells for training sessions
- Support training to include equipment preparation pre and post use (upstream, downstream, fill finish)
- Daily operations to include COP/SOP, autoclave, parts washer, solution preparation, cell culture
- Implement and maintain documentation for the NIBRT facility (SOP’s, production batch records,) according to GMP/GDP requirements.
- Control and organize ordering of lab and plant consumables
- Assist with training and project work as required
Requirements:
- Applicants will be expected to hold a minimum Level 8 qualification in a related scientific field (Life Science/Biopharmaceutical Processing/Engineering).
- Previous hands on practical experience of mammalian cell culture would be a distinct advantage.
- Previous hands on practical experience of preparation of processing equipment including bioreactors, chromatography column packing, autoclaves, parts washers, COP and SOP of stainless steel vessels would be a distinct advantage.
- Previous experience in a regulated industrial biopharmaceutical process environment would be a distinct advantage.
- The successful technician will be a motivated self-starter, capable of working under their own initiative and as part of a busy training team.
- High level of attention to detail and strong problem-solving skills required.
Terms and Conditions of Employment
- This is a permanent position
- Competitive remuneration package available
- You must be eligible to work in Ireland to apply for this position
How to Apply:
To apply for this position please forward your CV, cover letter and the names and contact details of two referees in a combined PDF document to NIBRT HR department at careers@nibrt.ie. Please include your name and the position for which you are applying – Bioprocessing Technician Ref: BT11/2019 - in the subject line. Please note that the successful candidate may be required to supply parchments of degrees / qualifications.
Closing date: 5pm on Friday, 22nd November 2019
NIBRT is an equal opportunities employer.
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Job Opportunity Questions?
If you have any questions about one of our vacant roles, please contact us and we will get back to you as soon as possible.