Course Descriptor

Cellular Immunotherapy is a subset of Advanced Therapy that uses cells of the immune system to treat diseases such as cancer. The most well-known type of Cellular Immunotherapy is CAR-T; a treatment that uses genetically modified immune cells (T cells) to target and kill cancerous cells.

This course will provide a description of the theory underlying CAR-T as well as other Cellular Immunotherapy modalities, including CAR-NK, TILs, and cancer vaccines. In addition, the course will describe the difference between autologous and allogeneic forms of these therapies as well as the associated advantages and disadvantages of each approach. The manufacture of these therapies will also be discussed as well as key QC requirements and the difficulties associated with ensuring quality product.

In addition to the theoretical learning, significant time will be spent working with cells in a Cellular Immunotherapy manufacturing workflow. Trainees will interact with equipment associated with all steps of the manufacturing process, from cell thaw (controlled thaw of Leukopak) through to cell isolation (density gradient centrifuge), modification and expansion (rocker bioreactor), purification (centrifuge), and cryopreservation (controlled rate freezer).

2 Days Onsite in NIBRT

Introduction to Cellular Immunotherapy

SKU: Introduction-to-Cellular-Immunotherapy Category:

1,760.00

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Dates:
  • 06/09/2022 - 07/09/2022

    3 Places Remaining

Fee:
€1760
Suitable for:

This course would benefit anyone who already has an understanding of biopharmaceutical manufacture but would like to gain some further insight into the manufacture of cell therapies, in particular, cellular immunotherapy.

Who should attend

This course would benefit anyone who already has an understanding of biopharmaceutical manufacture but would like to gain some further insight into the manufacture of cell therapies, in particular, cellular immunotherapy.

Key topics covered

  • Definition of the concept of cell therapy and ex vivo gene therapy
  • The difference between allogeneic and autologous therapies.
  • Introduction to the function of the human immune system
  • Description of the process of adoptive cell transfer
  • How modification of cells is performed for therapeutic purposes.
  • The mechanism of action of CAR-T, CAR-NK, TCR, TILs, and other cellular immunotherapies
  • The manufacturing workflow for this class of therapy
  • Overview of the QC steps associated with cell therapy manufacture
  • The handling and thawing of cryo-stored leukapheresis material
  • Cell enrichment and isolation using centrifugation and magnetic beads
  • Cell expansion using rocker bioreactors and perfusion systems
  • Harvest, formulation, and cryopreservation using centrifugation and controlled rate freezing

Assessment

Trainees will receive a certificate of completion for attending all parts of the course and for passing a short post-course assessment. 

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